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Circulating miRNAs Are Associated with Inflammation Biomarkers in Children with Overweight and Obesity: Results of the I.Family Study.
Genes (Basel). 2022 04 01; 13(4)G

Abstract

Increasing data suggest that overnutrition-induced obesity may trigger an inflammatory process in adipose tissue and upturn in the innate immune system. Numerous players have been involved in governing the inflammatory response, including epigenetics. Among epigenetic players, miRNAs are emerging as crucial regulators of immune cell development, immune responses, autoimmunity, and inflammation. In this study, we aimed at identifying the involvement of candidate miRNAs in relation to inflammation-associated biomarkers in a subsample of European children with overweight and obesity participating in the I.Family study. The study sample included individuals with increased adiposity since this condition contributes to the early occurrence of chronic low-grade inflammation. We focused on the acute-phase reagent C-reactive protein (CRP) as the primary outcome and selected cytokines as plausible biomarkers of inflammation. We found that chronic low-grade CRP elevation shows a highly significant association with miR-26b-3p and hsa-miR-576-5p in boys. Furthermore, the association of CRP with hsa-miR-10b-5p and hsa-miR-31-5p is highly significant in girls. We also observed major sex-related associations of candidate miRNAs with selected cytokines. Except for IL-6, a significant association of hsa-miR-26b-3p and hsa-miR-576-5p with TNF-α, IL1-Ra, IL-8, and IL-15 levels was found exclusively in boys. The findings of this exploratory study suggest sex differences in the association of circulating miRNAs with inflammatory response biomarkers, and indicate a possible role of miRNAs among the candidate epigenetic mechanisms related to the process of low-grade inflammation in childhood obesity.

Authors+Show Affiliations

Institute of Food Sciences, National Research Council, 83100 Avellino, Italy.Institute of Food Sciences, National Research Council, 83100 Avellino, Italy.Institute of Food Sciences, National Research Council, 83100 Avellino, Italy.Institute of Food Sciences, National Research Council, 83100 Avellino, Italy.Institute of Food Sciences, National Research Council, 83100 Avellino, Italy.Leibniz Institute for Prevention Research and Epidemiology-BIPS, Achterstraβe 30, 28359 Bremen, Germany.Department of Public Health and Primary Care, University Hospital 4K3 C. Heymanslaan, 10, 9000 Ghent, Belgium.Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 3, 41390 Göteborg, Sweden.Leibniz Institute for Prevention Research and Epidemiology-BIPS, Achterstraβe 30, 28359 Bremen, Germany.Leibniz Institute for Prevention Research and Epidemiology-BIPS, Achterstraβe 30, 28359 Bremen, Germany.Research and Education Institute of Child Health, 138 Limassol Ave, #205, Strovolos 2015, Cyprus.Department of Pediatrics, Medical School, University of Pécs, H-7624 Pecs, Hungary.University of Zaragoza, Domingo Miral s/n, 50009 Zaragoza, Spain.National Institute for Health Development, Hiiu 42, 11619 Tallinn, Estonia.Institute of Food Sciences, National Research Council, 83100 Avellino, Italy.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

35456438

Citation

Lauria, Fabio, et al. "Circulating miRNAs Are Associated With Inflammation Biomarkers in Children With Overweight and Obesity: Results of the I.Family Study." Genes, vol. 13, no. 4, 2022.
Lauria F, Iacomino G, Russo P, et al. Circulating miRNAs Are Associated with Inflammation Biomarkers in Children with Overweight and Obesity: Results of the I.Family Study. Genes (Basel). 2022;13(4).
Lauria, F., Iacomino, G., Russo, P., Venezia, A., Marena, P., Ahrens, W., De Henauw, S., Eiben, G., Foraita, R., Hebestreit, A., Kourides, Y., Molnár, D., Moreno, L. A., Veidebaum, T., & Siani, A. (2022). Circulating miRNAs Are Associated with Inflammation Biomarkers in Children with Overweight and Obesity: Results of the I.Family Study. Genes, 13(4). https://doi.org/10.3390/genes13040632
Lauria F, et al. Circulating miRNAs Are Associated With Inflammation Biomarkers in Children With Overweight and Obesity: Results of the I.Family Study. Genes (Basel). 2022 04 1;13(4) PubMed PMID: 35456438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating miRNAs Are Associated with Inflammation Biomarkers in Children with Overweight and Obesity: Results of the I.Family Study. AU - Lauria,Fabio, AU - Iacomino,Giuseppe, AU - Russo,Paola, AU - Venezia,Antonella, AU - Marena,Pasquale, AU - Ahrens,Wolfgang, AU - De Henauw,Stefaan, AU - Eiben,Gabriele, AU - Foraita,Ronja, AU - Hebestreit,Antje, AU - Kourides,Yiannis, AU - Molnár,Dénes, AU - Moreno,Luis A, AU - Veidebaum,Toomas, AU - Siani,Alfonso, AU - ,, Y1 - 2022/04/01/ PY - 2022/02/22/received PY - 2022/03/25/revised PY - 2022/03/29/accepted PY - 2022/4/23/entrez PY - 2022/4/24/pubmed PY - 2022/4/27/medline KW - children/adolescents KW - chronic low-grade inflammation KW - inflammation-associated biomarkers KW - miRNAs KW - overweight and obesity KW - sex-related associations JF - Genes JO - Genes (Basel) VL - 13 IS - 4 N2 - Increasing data suggest that overnutrition-induced obesity may trigger an inflammatory process in adipose tissue and upturn in the innate immune system. Numerous players have been involved in governing the inflammatory response, including epigenetics. Among epigenetic players, miRNAs are emerging as crucial regulators of immune cell development, immune responses, autoimmunity, and inflammation. In this study, we aimed at identifying the involvement of candidate miRNAs in relation to inflammation-associated biomarkers in a subsample of European children with overweight and obesity participating in the I.Family study. The study sample included individuals with increased adiposity since this condition contributes to the early occurrence of chronic low-grade inflammation. We focused on the acute-phase reagent C-reactive protein (CRP) as the primary outcome and selected cytokines as plausible biomarkers of inflammation. We found that chronic low-grade CRP elevation shows a highly significant association with miR-26b-3p and hsa-miR-576-5p in boys. Furthermore, the association of CRP with hsa-miR-10b-5p and hsa-miR-31-5p is highly significant in girls. We also observed major sex-related associations of candidate miRNAs with selected cytokines. Except for IL-6, a significant association of hsa-miR-26b-3p and hsa-miR-576-5p with TNF-α, IL1-Ra, IL-8, and IL-15 levels was found exclusively in boys. The findings of this exploratory study suggest sex differences in the association of circulating miRNAs with inflammatory response biomarkers, and indicate a possible role of miRNAs among the candidate epigenetic mechanisms related to the process of low-grade inflammation in childhood obesity. SN - 2073-4425 UR - https://cancerres.unboundmedicine.com/medline/citation/35456438/Circulating_miRNAs_Are_Associated_with_Inflammation_Biomarkers_in_Children_with_Overweight_and_Obesity:_Results_of_the_I_Family_Study_ DB - PRIME DP - Unbound Medicine ER -