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The association of circulating miR-191 and miR-375 expression levels with markers of insulin resistance in overweight children: an exploratory analysis of the I.Family Study.
Genes Nutr. 2021 Jul 09; 16(1):10.GN

Abstract

BACKGROUND

In recent years, the exciting emergence of circulating miRNAs as stable, reproducible, and consistent among individuals has opened a promising research opportunity for the detection of non-invasive biomarkers. A firm connection has been established between circulating miRNAs and glycaemic as well as metabolic homeostasis, showing that levels of specific miRNAs vary under different physio-pathological conditions.

OBJECTIVE

In this pilot study, we investigated the expression of candidate miRNAs, hsa-miR-191-3p and hsa-miR-375, in relation to biomarkers associated with insulin sensitivity in a subgroup (n=58) of subjects participating to the European I.Family Study, a project aimed to assess the determinants of eating behaviour in children and adolescents and related health outcomes. The sample included overweight/obese children/adolescents since overweight/obesity is a known risk factor for impaired glucose homeostasis and metabolic disorders. Biological targets of candidate miRNAs were also explored in silico.

RESULTS

We observed a significant association of the two miRNAs and early changes in glycaemic homeostasis, independent of covariates including country of origin, age, BMI z-score, puberty status, highest educational level of parents, total energy intake, energy from fats, energy from carbohydrates, and energy from proteins.

CONCLUSION

Identification of circulating miRNAs associated with insulin impairment may offer novel approaches of assessing early variations in insulin sensitivity and provide evidence about the molecular mechanisms connected to early changes in glycaemic homeostasis.

TRIAL REGISTRATION

ISRCTN, ISRCTN62310987. Retrospectively registered, http://isrctn.com/ISRCTN62310987.

Authors+Show Affiliations

Institute of Food Sciences, National Research Council, ISA-CNR, via Roma 64, 83100, Avellino, Italy. piacomino@isa.cnr.it.Institute of Food Sciences, National Research Council, ISA-CNR, via Roma 64, 83100, Avellino, Italy.Institute of Food Sciences, National Research Council, ISA-CNR, via Roma 64, 83100, Avellino, Italy.Institute of Food Sciences, National Research Council, ISA-CNR, via Roma 64, 83100, Avellino, Italy.Institute of Food Sciences, National Research Council, ISA-CNR, via Roma 64, 83100, Avellino, Italy.Institute of Food Sciences, National Research Council, ISA-CNR, via Roma 64, 83100, Avellino, Italy.Leibniz Institute for Prevention Research and Epidemiology, BIPS, Achterstraβe 30, 28359, Bremen, Germany.University of Ghent, C. Heymanslaan 10, 4K3, 9000, Ghent, Belgium.Department of Pediatrics, Medical School, University of Pécs, Pécs, Hungary.Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 3, 413 90, Göteborg, Sweden.Leibniz Institute for Prevention Research and Epidemiology, BIPS, Achterstraβe 30, 28359, Bremen, Germany.Leibniz Institute for Prevention Research and Epidemiology, BIPS, Achterstraβe 30, 28359, Bremen, Germany.Research and Education Institute of Child Health, ave, #205 2015, Strovolos, 138, Limassol, Cyprus.University of Zaragoza, Domingo Miral, s/n, 50009, Zaragoza, Spain.National Institute for Health Development, Hiiu 42, 11619, Tallinn, Estonia.Institute of Food Sciences, National Research Council, ISA-CNR, via Roma 64, 83100, Avellino, Italy.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34243726

Citation

Iacomino, Giuseppe, et al. "The Association of Circulating miR-191 and miR-375 Expression Levels With Markers of Insulin Resistance in Overweight Children: an Exploratory Analysis of the I.Family Study." Genes & Nutrition, vol. 16, no. 1, 2021, p. 10.
Iacomino G, Lauria F, Russo P, et al. The association of circulating miR-191 and miR-375 expression levels with markers of insulin resistance in overweight children: an exploratory analysis of the I.Family Study. Genes Nutr. 2021;16(1):10.
Iacomino, G., Lauria, F., Russo, P., Venezia, A., Iannaccone, N., Marena, P., Ahrens, W., De Henauw, S., Molnár, D., Eiben, G., Foraita, R., Hebestreit, A., Kourides, G., Moreno, L. A., Veidebaum, T., & Siani, A. (2021). The association of circulating miR-191 and miR-375 expression levels with markers of insulin resistance in overweight children: an exploratory analysis of the I.Family Study. Genes & Nutrition, 16(1), 10. https://doi.org/10.1186/s12263-021-00689-1
Iacomino G, et al. The Association of Circulating miR-191 and miR-375 Expression Levels With Markers of Insulin Resistance in Overweight Children: an Exploratory Analysis of the I.Family Study. Genes Nutr. 2021 Jul 9;16(1):10. PubMed PMID: 34243726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of circulating miR-191 and miR-375 expression levels with markers of insulin resistance in overweight children: an exploratory analysis of the I.Family Study. AU - Iacomino,Giuseppe, AU - Lauria,Fabio, AU - Russo,Paola, AU - Venezia,Antonella, AU - Iannaccone,Nunzia, AU - Marena,Pasquale, AU - Ahrens,Wolfgang, AU - De Henauw,Stefaan, AU - Molnár,Dénes, AU - Eiben,Gabriele, AU - Foraita,Ronja, AU - Hebestreit,Antje, AU - Kourides,Giannis, AU - Moreno,Luis A, AU - Veidebaum,Toomas, AU - Siani,Alfonso, AU - ,, Y1 - 2021/07/09/ PY - 2021/03/10/received PY - 2021/05/18/accepted PY - 2021/7/10/entrez PY - 2021/7/11/pubmed PY - 2021/7/11/medline KW - Biomarkers KW - Children/adolescents KW - Insulin impairment KW - MicroRNAs KW - Overweight/obese SP - 10 EP - 10 JF - Genes & nutrition JO - Genes Nutr VL - 16 IS - 1 N2 - BACKGROUND: In recent years, the exciting emergence of circulating miRNAs as stable, reproducible, and consistent among individuals has opened a promising research opportunity for the detection of non-invasive biomarkers. A firm connection has been established between circulating miRNAs and glycaemic as well as metabolic homeostasis, showing that levels of specific miRNAs vary under different physio-pathological conditions. OBJECTIVE: In this pilot study, we investigated the expression of candidate miRNAs, hsa-miR-191-3p and hsa-miR-375, in relation to biomarkers associated with insulin sensitivity in a subgroup (n=58) of subjects participating to the European I.Family Study, a project aimed to assess the determinants of eating behaviour in children and adolescents and related health outcomes. The sample included overweight/obese children/adolescents since overweight/obesity is a known risk factor for impaired glucose homeostasis and metabolic disorders. Biological targets of candidate miRNAs were also explored in silico. RESULTS: We observed a significant association of the two miRNAs and early changes in glycaemic homeostasis, independent of covariates including country of origin, age, BMI z-score, puberty status, highest educational level of parents, total energy intake, energy from fats, energy from carbohydrates, and energy from proteins. CONCLUSION: Identification of circulating miRNAs associated with insulin impairment may offer novel approaches of assessing early variations in insulin sensitivity and provide evidence about the molecular mechanisms connected to early changes in glycaemic homeostasis. TRIAL REGISTRATION: ISRCTN, ISRCTN62310987. Retrospectively registered, http://isrctn.com/ISRCTN62310987. SN - 1555-8932 UR - https://cancerres.unboundmedicine.com/medline/citation/34243726/The_association_of_circulating_miR-191_and_miR-375_expression_levels_with_markers_of_insulin_resistance_in_overweight_children:_an_exploratory_analysis_of_the_I.Family_Study. L2 - https://dx.doi.org/10.1186/s12263-021-00689-1 DB - PRIME DP - Unbound Medicine ER -
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