Citation
Ardissino, Gianluigi, et al. "Is Shigatoxin 1 Protective for the Development of Shigatoxin 2-related Hemolytic Uremic Syndrome in Children? Data From the ItalKid-HUS Network." Pediatric Nephrology (Berlin, Germany), vol. 35, no. 10, 2020, pp. 1997-2001.
Ardissino G, Possenti I, Vignati C, et al. Is Shigatoxin 1 protective for the development of Shigatoxin 2-related hemolytic uremic syndrome in children? Data from the ItalKid-HUS Network. Pediatr Nephrol. 2020;35(10):1997-2001.
Ardissino, G., Possenti, I., Vignati, C., Daprai, L., Capone, V., Brigotti, M., Luini, M. V., Consonni, D., & Montini, G. (2020). Is Shigatoxin 1 protective for the development of Shigatoxin 2-related hemolytic uremic syndrome in children? Data from the ItalKid-HUS Network. Pediatric Nephrology (Berlin, Germany), 35(10), 1997-2001. https://doi.org/10.1007/s00467-020-04697-y
Ardissino G, et al. Is Shigatoxin 1 Protective for the Development of Shigatoxin 2-related Hemolytic Uremic Syndrome in Children? Data From the ItalKid-HUS Network. Pediatr Nephrol. 2020;35(10):1997-2001. PubMed PMID: 32734345.
TY - JOUR
T1 - Is Shigatoxin 1 protective for the development of Shigatoxin 2-related hemolytic uremic syndrome in children? Data from the ItalKid-HUS Network.
AU - Ardissino,Gianluigi,
AU - Possenti,Ilaria,
AU - Vignati,Chiara,
AU - Daprai,Laura,
AU - Capone,Valentina,
AU - Brigotti,Maurizio,
AU - Luini,Mario Vittorio,
AU - Consonni,Dario,
AU - Montini,Giovanni,
Y1 - 2020/07/30/
PY - 2020/02/28/received
PY - 2020/06/25/accepted
PY - 2020/06/16/revised
PY - 2020/8/1/pubmed
PY - 2021/7/3/medline
PY - 2020/8/1/entrez
KW - Children
KW - Diarrhea
KW - Hemolytic uremic syndrome
KW - Shiga toxin
SP - 1997
EP - 2001
JF - Pediatric nephrology (Berlin, Germany)
JO - Pediatr Nephrol
VL - 35
IS - 10
N2 - BACKGROUND: Shigatoxin (Stx)-producing Escherichia coli (STEC) are the most common causes of hemolytic uremic syndrome (STEC-HUS). The aim of our study is to compare the risk of developing STEC-HUS in relation to the type of Stx genes (Stx1, Stx2, or both). METHODS: This is a prospective, observational, multicenter study involving 63 pediatric units in Northern Italy (ItalKid-HUS Network). STEC-infected children were identified within a screening program for bloody diarrhea during a 10-year period (2010-2019). Stx genes were detected by reverse dot blot or real-time PCR. After the identification of STEC infection, children were followed until diarrhea complete recovery for the possible development of STEC-HUS. RESULTS: Of the 214 Stx-positive patients, 34 (15.9%) developed STEC-HUS. The risk of HUS in STEC-infected children with Stx1 (n: 62; 29.0%) and Stx2 (n: 97; 45.3%) was respectively 0% and 23.7%, while in patients carrying both Stx1 and Stx2 (n: 55; 25.7%), the risk was 12.7% (p: 0.001). CONCLUSIONS: Our data confirm that Stx1 is a very rare cause of STEC-HUS and demonstrate that the risk of STEC-HUS halves in the case of Stx1+2-producing Escherichia coli infection compared with infections where Stx2 is present alone. This observation is helpful in assessing the risk of individual STEC-infected patients for the development of HUS and suggests that Stx1, in the presence of Stx2, might exert a protective role possibly by receptor competition.
SN - 1432-198X
UR - https://cancerres.unboundmedicine.com/medline/citation/32734345/Is_Shigatoxin_1_protective_for_the_development_of_Shigatoxin_2_related_hemolytic_uremic_syndrome_in_children_Data_from_the_ItalKid_HUS_Network_
L2 - https://dx.doi.org/10.1007/s00467-020-04697-y
DB - PRIME
DP - Unbound Medicine
ER -
