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Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review.
Nutrients. 2019 Nov 27; 11(12)N

Abstract

Early detection of obesity and its associated comorbidities in children needs priority for the development of effective therapeutic intervention. Circulating miRNAs (microRNAs) have been proposed as biomarkers for obesity and its comorbidities; therefore, we conducted a systematic review to summarize results of studies that have quantified the profile of miRNAs in children and adolescents with obesity and/or associated disorders. Nine studies aiming to examine differences in miRNA expression levels between children with normal weight and obesity or between obese children with or without cardiometabolic diseases were included in this review. We identified four miRNAs overexpressed in obesity (miR-222, miR-142-3, miR-140-5p, and miR-143) and two miRNAs (miR-122 and miR-34a) overexpressed in children with obesity and nonalcoholic fatty liver disease (NAFLD) and/or insulin resistance. In conclusion, circulating miRNAs are promising diagnostic biomarkers of obesity-associated diseases such as NAFLD and type 2 diabetes already in childhood. However, more studies in children, using massive search technology and with larger sample sizes, are required to draw any firm conclusions.

Authors+Show Affiliations

Institute for Innovation & Sustainable Development in Food Chain, Public University of Navarre, Jeronimo de Ayanz Building, Campus de Arrosadia, 31006 Pamplona, Spain.TECNALIA, Parque Tecnológico de Álava, Leonardo Da Vinci, 11, 01510 Miñano, Spain.Nutrition and Obesity Group, Department of Nutrition and Food Science, Public University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, 01006 Vitoria, Spain. CIBEROBN (Physiopathology of Obesity and Nutrition Network CB12/03/30038), Health Institute Carlos III (ISCIII), 28029 Madrid, Spain. Instituto de Investigación Sanitaria BIOARABA, 01006 Vitoria, Spain.CIBEROBN (Physiopathology of Obesity and Nutrition Network CB12/03/30038), Health Institute Carlos III (ISCIII), 28029 Madrid, Spain. Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, Avda. del Conocimiento s/n, 18016 Armilla, Spain. Instituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain.Institute for Innovation & Sustainable Development in Food Chain, Public University of Navarre, Jeronimo de Ayanz Building, Campus de Arrosadia, 31006 Pamplona, Spain.

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

31783635

Citation

Oses, Maddi, et al. "Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: a Systematic Review." Nutrients, vol. 11, no. 12, 2019.
Oses M, Margareto Sanchez J, Portillo MP, et al. Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review. Nutrients. 2019;11(12).
Oses, M., Margareto Sanchez, J., Portillo, M. P., Aguilera, C. M., & Labayen, I. (2019). Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review. Nutrients, 11(12). https://doi.org/10.3390/nu11122890
Oses M, et al. Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: a Systematic Review. Nutrients. 2019 Nov 27;11(12) PubMed PMID: 31783635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review. AU - Oses,Maddi, AU - Margareto Sanchez,Javier, AU - Portillo,Maria P, AU - Aguilera,Concepción María, AU - Labayen,Idoia, Y1 - 2019/11/27/ PY - 2019/10/21/received PY - 2019/11/11/revised PY - 2019/11/25/accepted PY - 2019/12/1/entrez PY - 2019/12/1/pubmed PY - 2020/5/12/medline KW - biomarkers KW - childhood obesity KW - miRNAs JF - Nutrients JO - Nutrients VL - 11 IS - 12 N2 - Early detection of obesity and its associated comorbidities in children needs priority for the development of effective therapeutic intervention. Circulating miRNAs (microRNAs) have been proposed as biomarkers for obesity and its comorbidities; therefore, we conducted a systematic review to summarize results of studies that have quantified the profile of miRNAs in children and adolescents with obesity and/or associated disorders. Nine studies aiming to examine differences in miRNA expression levels between children with normal weight and obesity or between obese children with or without cardiometabolic diseases were included in this review. We identified four miRNAs overexpressed in obesity (miR-222, miR-142-3, miR-140-5p, and miR-143) and two miRNAs (miR-122 and miR-34a) overexpressed in children with obesity and nonalcoholic fatty liver disease (NAFLD) and/or insulin resistance. In conclusion, circulating miRNAs are promising diagnostic biomarkers of obesity-associated diseases such as NAFLD and type 2 diabetes already in childhood. However, more studies in children, using massive search technology and with larger sample sizes, are required to draw any firm conclusions. SN - 2072-6643 UR - https://cancerres.unboundmedicine.com/medline/citation/31783635/Circulating_miRNAs_as_Biomarkers_of_Obesity_and_Obesity_Associated_Comorbidities_in_Children_and_Adolescents:_A_Systematic_Review_ DB - PRIME DP - Unbound Medicine ER -