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Circulating microRNAs and adipokines as markers of metabolic syndrome in adolescents with obesity.
Clin Nutr. 2019 10; 38(5):2231-2238.CN

Abstract

BACKGROUND

Circulating microRNAs (miRNAs) as valuable biomarkers yielded important insights into the pathogenesis of obesity.

AIM

This study aimed to describe the circulating miRNA profile for adolescences and its association with the circulating levels leptin and adiponectin according to specific degree of obesity.

METHODS

RT-PCR and immunoassy analysis were used to study circulating miRNA profile, adipokines; adiponectin (A), leptin (L), and L/A ratio as well as other factors of metabolic syndrome (MS) in 250 adolescents with severe obesity.

RESULTS

In morbidly obese adolescents, we identified at least 10 circulating miRNAs, including increased concentrations of miRNAS; miR-142-3p, miR-140-5p, miR-222 miR-143, miR-130, and decreased concentrations of miR-532-5p, miR-423-5p, miR-520c-3p, miR-146a, and miR-15a, which were strongly linked to measures of BMI, WHtR, adipokines; adiponectin, leptin, L/A ratio, and other MS related biomarkers such as FBS, insulin, HOMA-IR, C-peptide, and circulated plasma lipids such as TG, HDL-C, and LDL-C.

CONCLUSION

Circulating miRNAs showed significant association with plasma levels of adipokines; adiponectin, leptin, and L/A ratios in adolescents with severe obesity. The study provides that regulation of miRNAs expression is associated with adipokines, and other related MS metabolic factors. Thus, early detection of any changes in circulating miRNAs profiles may play a promising role in identifying obese children or adolescents who may suffer from severe metabolic syndrome.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Al-Rawaf HA
Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia. Electronic address: dr.hadeel2018@gmail.com.

MeSH

AdipokinesAdolescentBiomarkersChildCirculating MicroRNACross-Sectional StudiesFemaleHumansMaleMetabolic SyndromeObesity, MorbidPediatric Obesity

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30309709

Citation

Al-Rawaf, Hadeel A.. "Circulating microRNAs and Adipokines as Markers of Metabolic Syndrome in Adolescents With Obesity." Clinical Nutrition (Edinburgh, Scotland), vol. 38, no. 5, 2019, pp. 2231-2238.
Al-Rawaf HA. Circulating microRNAs and adipokines as markers of metabolic syndrome in adolescents with obesity. Clin Nutr. 2019;38(5):2231-2238.
Al-Rawaf, H. A. (2019). Circulating microRNAs and adipokines as markers of metabolic syndrome in adolescents with obesity. Clinical Nutrition (Edinburgh, Scotland), 38(5), 2231-2238. https://doi.org/10.1016/j.clnu.2018.09.024
Al-Rawaf HA. Circulating microRNAs and Adipokines as Markers of Metabolic Syndrome in Adolescents With Obesity. Clin Nutr. 2019;38(5):2231-2238. PubMed PMID: 30309709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating microRNAs and adipokines as markers of metabolic syndrome in adolescents with obesity. A1 - Al-Rawaf,Hadeel A, Y1 - 2018/09/25/ PY - 2018/05/01/received PY - 2018/09/17/revised PY - 2018/09/18/accepted PY - 2018/10/13/pubmed PY - 2020/9/26/medline PY - 2018/10/13/entrez KW - Adolescents KW - Leptin-adiponectin imbalance KW - MicroRNAs KW - Obesity SP - 2231 EP - 2238 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 38 IS - 5 N2 - BACKGROUND: Circulating microRNAs (miRNAs) as valuable biomarkers yielded important insights into the pathogenesis of obesity. AIM: This study aimed to describe the circulating miRNA profile for adolescences and its association with the circulating levels leptin and adiponectin according to specific degree of obesity. METHODS: RT-PCR and immunoassy analysis were used to study circulating miRNA profile, adipokines; adiponectin (A), leptin (L), and L/A ratio as well as other factors of metabolic syndrome (MS) in 250 adolescents with severe obesity. RESULTS: In morbidly obese adolescents, we identified at least 10 circulating miRNAs, including increased concentrations of miRNAS; miR-142-3p, miR-140-5p, miR-222 miR-143, miR-130, and decreased concentrations of miR-532-5p, miR-423-5p, miR-520c-3p, miR-146a, and miR-15a, which were strongly linked to measures of BMI, WHtR, adipokines; adiponectin, leptin, L/A ratio, and other MS related biomarkers such as FBS, insulin, HOMA-IR, C-peptide, and circulated plasma lipids such as TG, HDL-C, and LDL-C. CONCLUSION: Circulating miRNAs showed significant association with plasma levels of adipokines; adiponectin, leptin, and L/A ratios in adolescents with severe obesity. The study provides that regulation of miRNAs expression is associated with adipokines, and other related MS metabolic factors. Thus, early detection of any changes in circulating miRNAs profiles may play a promising role in identifying obese children or adolescents who may suffer from severe metabolic syndrome. SN - 1532-1983 UR - https://cancerres.unboundmedicine.com/medline/citation/30309709/Circulating_microRNAs_and_adipokines_as_markers_of_metabolic_syndrome_in_adolescents_with_obesity_ DB - PRIME DP - Unbound Medicine ER -