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Protective effect of antioxidants on blood oxidative stress caused by arginine.
Fundam Clin Pharmacol. 2012 Apr; 26(2):250-8.FC

Abstract

In this study, we investigated in vivo and in vitro effect of arginine on parameters of oxidative stress namely thiobarbituric acid-reactive substances (TBA-RS) and total radical-trapping antioxidant parameter (TRAP) in plasma and on the antioxidant enzymes activities catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) in erythrocytes of rats. Results showed that acute administration reduced TRAP and CAT activity and increased TBA-RS. Furthermore, in vitro studies did not alter oxidative parameters studied. The influence of N(ω)-nitro-L-arginine methyl ester (L-NAME) and antioxidants (α-tocopherol plus ascorbic acid) on the effects elicited by arginine was also studied. In addition, simultaneous injection of L-NAME or treatment with antioxidants prevented the alteration on TRAP, TBA-RS, and CAT activity caused by arginine. Data indicate that oxidative stress induction is probably mediated by the generation of NO and/or ONOO(-) and other free radicals, because L-NAME and these antioxidants prevented these effects caused by arginine.

Authors+Show Affiliations

Departamento de Medicina, Universidade da Região de Joinville- UNIVILLE, Campus Universitário, Bairro Bom Retiro, CEP 89201-972, Joinville, SC, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21210846

Citation

de Lima, Daniela Delwing, et al. "Protective Effect of Antioxidants On Blood Oxidative Stress Caused By Arginine." Fundamental & Clinical Pharmacology, vol. 26, no. 2, 2012, pp. 250-8.
de Lima DD, Delwing F, da Cruz JG, et al. Protective effect of antioxidants on blood oxidative stress caused by arginine. Fundam Clin Pharmacol. 2012;26(2):250-8.
de Lima, D. D., Delwing, F., da Cruz, J. G., Wyse, A. T., & Delwing-Dal Magro, D. (2012). Protective effect of antioxidants on blood oxidative stress caused by arginine. Fundamental & Clinical Pharmacology, 26(2), 250-8. https://doi.org/10.1111/j.1472-8206.2010.00909.x
de Lima DD, et al. Protective Effect of Antioxidants On Blood Oxidative Stress Caused By Arginine. Fundam Clin Pharmacol. 2012;26(2):250-8. PubMed PMID: 21210846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of antioxidants on blood oxidative stress caused by arginine. AU - de Lima,Daniela Delwing, AU - Delwing,Fábio, AU - da Cruz,José Geraldo Pereira, AU - Wyse,Angela Terezinha Souza, AU - Delwing-Dal Magro,Débora, Y1 - 2011/01/07/ PY - 2011/1/8/entrez PY - 2011/1/8/pubmed PY - 2012/7/10/medline SP - 250 EP - 8 JF - Fundamental & clinical pharmacology JO - Fundam Clin Pharmacol VL - 26 IS - 2 N2 - In this study, we investigated in vivo and in vitro effect of arginine on parameters of oxidative stress namely thiobarbituric acid-reactive substances (TBA-RS) and total radical-trapping antioxidant parameter (TRAP) in plasma and on the antioxidant enzymes activities catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) in erythrocytes of rats. Results showed that acute administration reduced TRAP and CAT activity and increased TBA-RS. Furthermore, in vitro studies did not alter oxidative parameters studied. The influence of N(ω)-nitro-L-arginine methyl ester (L-NAME) and antioxidants (α-tocopherol plus ascorbic acid) on the effects elicited by arginine was also studied. In addition, simultaneous injection of L-NAME or treatment with antioxidants prevented the alteration on TRAP, TBA-RS, and CAT activity caused by arginine. Data indicate that oxidative stress induction is probably mediated by the generation of NO and/or ONOO(-) and other free radicals, because L-NAME and these antioxidants prevented these effects caused by arginine. SN - 1472-8206 UR - https://cancerres.unboundmedicine.com/medline/citation/21210846/Protective_effect_of_antioxidants_on_blood_oxidative_stress_caused_by_arginine_ L2 - https://doi.org/10.1111/j.1472-8206.2010.00909.x DB - PRIME DP - Unbound Medicine ER -